Endocrine Abstracts

Introduction: In the last decades, primary hyperparathyroidism (PHPT) has changed in its clinical presentation, being mostly asymptomatic in western countries; in Romania is still common to see various clinical presentations.Objective: To characterize a retrospective cohort of PHPT Romanian patients.Patients and methods: 271 patients were included: 88% women, ratio F/M 7.5/1, mean age 60.6±12 yrs (15–83), mean BMI 26.3&#1...

Parathyroid carcinoma (PC) rarely presents with metastasis at diagnosis and usually in patients also having gross local invasion.Case presentation: We report the case of a 51-year-old postmenopausal woman presenting at our institution in June 2019 with symptomatic hypercalcemia (fatigue, polyuria, constipation and bone pain), but with a surprisingly good general condition. She had been treated with bisphosphonates for osteoporosis (DXA: LS T score &#8722...

Objectives: Mean TBS (Trabecular Bone Score) values are generally lower in PHPT (primary hyperparathyroidism) patients than controls. The aim of this study was to assess TBS from spine DXA images in patients with PHPT and look at its correlates.Methods: This was a cross-sectional study conducted in an osteoporosis referral center. One hundred and thirty six patients with PHPT were selected from our database (2010–2016) if they had a valid LS DXA sca...

Introduction: Successful parathyroid surgery in patients with OFC leads to early and marked improvements in BMD but data on very early changes in bone markers are missing.Case report: A 20-year-old girl was hospitalised because of severe bone pains and multiple pathological fractures (left humerus and left proximal femur) after minimal trauma. She had lost weight, was amenorrhoeic for the last 12 months and was bleeding from brown tumours in her mouth. S...

Introduction: Complete long-term clinical remission in occult ectopic ACTH syndrome after a single adrenalectomy is unexpected.Case report: 5 year ago, a 54-year-old man was admitted because of resistant HTA, multiple severe vertebral fractures, muscle weakness and cushingoid features of at least 1 year. Adrenal tests were diagnostic of ACTH-dependent Cushing’syndrome: ACTH=263 pg/ml, high plasma (62 μg/dl) and urinary free cortisol (UFC=1256 &...

The oral dosing with cholecalciferol needed to achieve and maintain optimal serum concentration 25-hydroxyvitamin D (25OHD) is still controversial.This study reports on the efficacy of supplementation with oral vitamin D3 1000 U/day for 3–18 months on serum 25OHD levels in 87 ambulatory patients with postmenopausal osteoporosis (mean age 63.5 years). Serum 25OHD, parathyroid hormone (PTH), calcium (serum, urine), phosphate, alkaline phosphatase and ...

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of chronic hypophosphatemia caused by the production of FGF23 in a typically small, benign, mesenchymal tumor. The diagnosis is often delayed and finding the tumor is sometimes challenging. We present a case of a 50 yrs old woman with TIO, referred to our clinic for progressive muscle weakness, diffuse bone pain and fractures, extensively investigated for 3 years. 2 years before admission she had a vertebroplas...

Introduction: Hungry bone syndrome (HBS) is a rare condition that can appear after surgery for hyperparathyroidism, characterized by hypocalcemia, hypophosphatemia, low calciuria, especially in patients with severe primary hyperparathyroidism, bone lesions and elevated alkaline phosphatase. We present a case of severe persistent hypocalcemia after resection of a giant parathyroid adenoma in a patient with concurrent osteoblastic bone metastasis from prostate cancer.<p clas...

Introduction: Multiple endocrine neoplasia type 2A is an autosomal dominant disorder which is characterized by the occurrence of medullary thyroid carcinoma in association with pheochromocytoma and parathyroid tumors.Case report: We present the case of a 64-year-old woman, with familial history of thyroid carcinoma, renal lithiasis and personal history of right nephrectomy for renal lithiasis, who presented for the investigation of a left lateral cervica...

Introduction: Clear cell renal carcinoma (ccRCC) is a subtype of renal cell carcinoma, the most frequent one (80%) and usually affecting only one kidney. It is twice as common in men than women between 50 to 70 years old. It can be associated with some genetic conditions that predispose patients to ccRCC, like Von Hipple-Lindau disease. Some clinical observations and molecular studies raised the hypothesis that RCC is a hormone−dependent tumor.Case...